Childbearing in coagulation disorders: Genetics (F2 and F5)

Congenital clotting disorders can be identified by changes in certain genes that affect blood clotting. These genetic mutations can increase the risk of thrombosis during pregnancy.

The most common hereditary thrombophilias are factor V Leiden and factor II (prothrombin), affecting between 3% and 11% of the population.

Individuals with a genetic predisposition to these clotting disorders may be at increased risk for developing deep vein thrombosis during pregnancy due to the increase in estrogens. In addition, such mutations may lead to an increased risk of recurrent miscarriage and pregnancy complications.

A predisposition to thrombophilia due to genetic factors can be determined by testing the genes involved in the blood clotting process (factor II, factor V). The mutations detected are subsequently analyzed.

Depending on the results, a close monitoring program or preventive measures, such as administration of low-dose aspirin, may be initiated.

Genes studied: F2, F5